七氟醚吸入麻醉与丙泊酚静脉麻醉在人工流产中的镇痛效果及不良反应对比

Comparison on analgesic effect and adverse reactions of sevoflurane inhalation anesthesia and propofol intravenous anesthesia in artificial abortion

目的探讨七氟醚吸入麻醉与丙泊酚静脉麻醉在人工流产中的镇痛效果及其安全性。方法 100例进行人工流产的早孕妇女,将其按照入院顺序编为1~100号,并按奇偶数分为吸入七氟醚组(奇数)与丙泊酚静脉麻醉组(偶数),每组50例。吸入七氟醚组采用全凭吸入七氟醚的方式麻醉,丙泊酚静脉麻醉组采用静脉注入丙泊酚进行麻醉。对比不同麻醉方式镇痛的效果及安全性。结果吸入七氟醚组镇痛效果优于丙泊酚静脉麻醉组,差异具有统计学意义(P<0.05)。吸入七氟醚组平均苏醒时间(2.02±0.98)min,短于丙泊酚静脉麻醉组的(5.81±1.77)min,差异具有统计学意义(P<0.05)。两组麻醉前血清S100β蛋白水平对比差异无统计学意义(P>0.05);吸入七氟醚组术后6、24、48、72 h血清S100β蛋白水平显著低于丙泊酚静脉麻醉组,差异均具有统计学意义(P<0.05)。吸入七氟醚组呼吸抑制、恶心呕吐发生率0、0均明显低于丙泊酚静脉麻醉组的16.0%、14.0%,差异均具有统计学意义(P<0.05);两组头晕头痛发生率比较差异无统计学意义(P>0.05)。结论七氟醚吸入在无痛人工流产中镇痛效果优于丙泊酚,苏醒快,安全性更高,值得临床加以推荐。

Objective To explore the analgesic effect and safety of sevoflurane inhalation anesthesia and propofol intravenous anesthesia in artificial abortion. Methods A total of 100 early pregnancy women with artificial abortion were numbered 1-100 by admission order and divided by odevity into sevoflurane inhalation group（odd number） and propofol intravenous anesthesia group（even number）, with 50 cases in each group. Sevoflurane inhalation group received sevoflurane inhalation for anesthesia, and propofol intravenous anesthesia group received intravenous injection of propofol for anesthesia. Comparison were made on analgesic effect and safety in different anesthesia Methods. Results Sevoflurane inhalation group had better analgesic effect than propofol intravenous anesthesia group, and the difference had statistical significance（P〈0.05）. Sevoflurane inhalation group had shorter average wake-up time as（2.02±0.98） min than（5.81±1.77） min in propofol intravenous anesthesia group, and the difference had statistical significance（P〈0.05）. Both groups had no statistically significant difference in serum S100β protein level before anesthesia（P〉0.05）. Sevoflurane inhalation group had significantly lower serum S100β protein level in postoperative 6, 24, 48 and 72 h than propofol intravenous anesthesia group, and their difference had statistical significance（P〈0.05）. Sevoflurane inhalation group had obviously lower incidence of respiratory depression, nausea and vomiting as 0 and 0 than 16.0% and 14.0% in propofol intravenous anesthesia group（P〈0.05）. Both groups had no statistically significant difference in incidence of dizziness and headache（P〉0.05）. Conclusion Sevoflurane inhalation shows better analgesic effect in artificial abortion than propofol with quick wake-up and high safety, and it is worthy of clinical recommendation.