胃肝样腺癌6例报告并文献复习

Report of 6 cases with hepatoid adenocarcinoma of the stomach and literature review

目的探讨胃肝样腺癌的诊断和治疗。方法回顾6例胃肝样腺癌的临床特点及其诊断和治疗。结果 6例胃肝样腺癌患者治疗前血清甲胎蛋白(AFP)均明显升高,行根治术2例,肝转移4例,脾肺转移各一例,均行XELOX化疗。其中2例失访,1例4个月后死亡,其余3例患者生存期分别为1~6个月、9个月、10个月。结论胃肝样腺癌是一类特殊的胃癌,容易发生淋巴结转移,肝转移,预后差。

Objective To investigate diagnosis and treatment of hepatoid adenocarcinoma of the stomach. Methods A retrospective analysis was made on clinical characteristics, diagnosis and treatment of 6 patients with hepatoid adenocarcinoma of the stomach. Results All 6 patients with gastric hepatoid adenocarcinoma showed increased serum alpha fetal protein（AFP） before treatment. Among them, there were 2 cases receiving radical operation. There were 4 cases with hepatic metastases, 1 case with splenic metastasis and 1 case with pulmonary metastasis, and they all received XELOX chemotherapy. There were 2 cases loss to follow-up and 1 death case after 4 months, and the other 3 cases had survival time respectively as 1-6 months, 9 months and 10 months. Conclusion As a special type of stomach cancer, hepatoid adenocarcinoma of the stomach shows easy trend of lymphatic metastasis and hepatic metastases, along with poor prognosis.