机体离子浓度对药物离子迁移率影响的模拟研究

Simulated study on the effect of the density of oganism ions on the removing rate of pharmaceutical ions

目的 研究机体离子浓度对药物离子迁移率的影响 ,为临床利用直流电离子透入疗法进行药物治疗提供实验依据。方法 采用模拟的方法 ,用稀盐酸 (HCI)中的氢离子 (H+ )代替药物离子 ,用稀盐水润湿了的滤纸代替机体 ,观察在电场力的作用下H+ 从正极向负极移动的情况。结果 H+ 的迁移率随稀盐水的浓度增加而减小。结论 相同浓度的药物离子 。

Objective: To study the effect of the density of organism ions on the removing rate of pharmaceutical ions and to provide an experimental basis for the pharmaceutical treatment of clinical DC penetrating therapy Methods: In simulated tests, The H + in rare Hcl was used for pharmaceutical ions and the filterpaper moistened with Nacl for organism, and the moving of H + from the positive pole to negative pole under the force of electric field was observed Results: The removing rate of H + in Hcl decreased as the density of Nacl solution in creased Conclusion: The removing rate of pharmaceutical ions of the same density changes with different organisms