腰臀比、血压及体重指数与其血清脂蛋白(a)浓度的相互关系研究

Study of the correlations among the serum lipoprotein(a) and waist-hip-ratio and blood pressure and body mass index

目的 探讨患者腰臀比 (WHR)、体重指数 (BMI)及血压 (BP)与其血清脂蛋白 (a) [Lp(a) ]浓度的相互关系。方法 四组研究对象共 116例 ,其中HBW组 2 9例及HB组 2 9例 ,BW组 2 9例 ,O组 2 9例为正常对照组。H :血压≥ 14 0 / 85mmHg ,B :BMI≥ 2 5 ,W :WHR≥ 0 85 / 0 90 (女 /男 ) ,O :血压、BMI、WHR均在正常范围。分别检测其甘油三脂 (TG)、总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL C)、高密度脂蛋白胆固醇 (HDL C)、Lp(a)、空腹血糖 (FPG)、糖化血红蛋白A1c(HbA1c)、C 肽 (C P)、胰岛素 (Ins)及BMI、WHR ,间隔 2周共测 4次 ,并测其血压。结果 HBW组患者Lp(a)水平较对照组升高具有显著性意义 (P <0 0 1) ,Ins水平较对照组升高明显 (P <0 0 5 ) ;HBW组较HB及BW组Lp(a)升高显著 (P <0 0 1) ;Lp(a)水平与HbA1c、C P水平无明显相关 (P >0 0 5 )。结论 腹型肥胖患者合并高血压易导致血清Lp(a)水平升高。这是肥胖并高血压患者致动脉粥样硬化 (AS)

Objective: To study the correlations among serum lipoprotein(a), waist hipratio(WHR), blood pressure(BP) and body mass index(BMI) Methods: 29 patients with HBW, 29 patients with HB and 29 patients with BW were in the observation group, and 29 patients with O were in the control gruop H stood for BP≥140/85 mmHg,B for BMI≥25,W for WHR≥0 85/0 9(female/male),O for BP, BMI and WHR were all normal The triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL C), high density lipoprotein cholesterol(HDL C), lipoprotein(a), fasting plasma glucose(FPG), hemoglobinA1c(HbA1c), c peptide(C P), insulin(Ins), body mass index(BMI) and BP were examined four times at a two week interval Results: The levels of Lp(a) increased significantly in the HBW group compared with those in the control group(P<0 01), and the Ins also increased significantly(P<0 05) The levels of the Lp(a) increased significantly (P<0 01) compared with those in the HB and BW groups The levels of the Lp(a) showed no correlation(P>0 05) with HbA1c, C P and Ins Conclusion: The patients with the type of central obesity can easily lead to higher Lp(a), which is an important risk factor of the atherosclerosis(AS) in the type of central obesity with hypertension