新生儿缺氧缺血性脑病与早产儿的关系

Relationship between neonatal hypoxic ischemic encephalopathy and premature infants

目的 探讨新生儿缺氧缺血性脑病 (HIE)与早产儿的关系。方法 对 2 74例HIE进行临床和CT分度 ,比较早产儿与足月儿的临床和CT分度之间的关系。分析了HIE并发症、后遗症的发生率与胎龄之间的关系。结果 早产儿与足月儿HIE的临床分度和CT分度之间差异均有显著意义 (χ2 =13 12 ,P <0 0 1;χ2 =5 2 3,P <0 0 5 ) ;早产儿的HIE分度比足月儿的分度重。早产儿的临床分度与CT分度基本一致 ,以中度为主 ;但是 ,足月儿的临床和CT分度一致性较差。早产儿与足月儿的HIE并发颅内出血及后遗症的发生率无明显差异 (χ2 =3 4 0 ,χ2 =1 35 ,均P >0 0 5 )。结论 在早产儿与足月儿的HIE的临床分度和CT分度均有明显差异。早产儿HIE的临床分度与CT分度基本一致 ,足月儿的一致性较差。HIE并发颅内出血及后遗症的发生率与胎龄无明显关系 ;

Objective: To investigate the relationship between neonatal hypoxic ischemic encephalopathy (HIE) and premature infants Methods: Two hundred and seventy four cases of HIE were classified according to their clinical and CT value for the analysis of the relation between the HIE clinical and CT grades in the premature infants and those in the term infants The relationship between the incidence rates of complications and sequelae of HIE and the gestational age was made Results: The difference was significant between the premature and the term infants in the clinical and CT grades of HIE (χ 2=13 2, P<0 01; χ 2=5 23, P<0 05, respectively) The HIE grades in the premature infants were higher than those in the term infants In the premature, the clinical grades corresponded with those of the CT in HIE, chiefly to the middle degree, while in the term infants, they showed differences There was no significant difference between the premature and term infants in the incidence rates of intracranial hemorrhage and sequelae of HIE (χ 2=3 40, P>0 05; χ 2=1 35, P>0 05 ) Conclusion: The difference is significant between the premature and the term infants in clinical and CT grades of HIE In premature infants, the HIE clinical grades and the HIE CT grades are identical, but they are slightly different in the term infants There is no significant relation between the incidence rates of intracranial hemorrhage and sequelae of HIE and the gestational age