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TGFβⅠ型和Ⅱ型受体在鼠磨牙牙胚发育过程中免疫组化定位及生物学意义探讨 被引量：1

Immunolocalization of TGFβ Receptor Type Ⅰ and Type Ⅱ during Mouse Molar Development.
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摘要 目的 :探讨TGFβI、II型受体在鼠磨牙牙胚发育过程中的生物学作用。 方法 :用免疫组织化学检测转化生长因子 βI型受体 (TβRI)、II型受体 (TβRII)在鼠下颌第一磨牙牙胚发育过程中的定位。 结果 :TβRⅠ、TβRⅡ在鼠磨牙牙胚发育过程中呈时间 -空间特异性分布 ,其分布模式与其配体TGFβ1～ 3蛋白的分布模式基本一致。 结论 :TβRⅠ、TβRⅡ在成釉器的早期形态发生。 Objective:To study the biological roles of TGFβ receptor type I and type II during mouse molar development.Methods:To examine the immunolocalization of TβRⅠ?TβRⅡ during mouse first lower molar development by immunohistochemistry.Results:The results showed that TβRⅠ?TβRⅡ were immunolocalized during mouse molar development in a temporally and spatially regulated fashion, and their localization patterns were mostly coincided with that of their ligands TGFβ1～3.Conclusions:Both TβRⅠand TβRⅡ might play important roles during early morphogenesis of enamel organ and the differentiation of ameloblast and odontoblast.
作者 朱奇 樊明文 陈智 张旗 边专 彭彬
机构地区 武汉大学口腔医学院
出处 《口腔医学研究》 CAS CSCD 2002年第4期239-241,T001,共4页 Journal of Oral Science Research
关键词 TGFβI型 磨牙牙胚 发育 免疫组化 生物学意义 转化生长因子Β 受体 TGFβⅡ型 Transforming growth factor-β Receptor Tooth germ Development
分类号 R780.2 [医药卫生—口腔医学]
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参考文献12

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同被引文献12

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口腔医学研究
2002年 第4期

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