氧疗配合重组表皮生长因子治疗宫颈癌放射性皮炎的效果观察及护理

Effect of oxygen therapy combined with recombinant epidermal growth factor on cervical cancer radiotherapy dermatitis

目的探讨氧疗配合重组表皮生长因子治疗宫颈癌放射性皮炎的效果及总结护理要点。方法按患者出现Ⅲ度放射性皮炎的日期进行随机分组,出现在单数日期的设为研究组,出现在双数日期的设为对照组,每组各35例。对照组患者放射性皮炎采用重组表皮生长因子治疗,研究组患者放射性皮炎采用氧疗配合重组表皮生长因子治疗。治疗后比较两组患者治疗效果、创面愈合时间及疼痛情况。结果两组患者治疗总有效率比较,P<0.01,差异具有统计学意义,研究组患者治疗总有效率明显高于对照组;两组患者创面愈合时间比较,P<0.001,差异具有统计学意义,研究组患者愈合时间明显短于对照组。结论采用氧疗配合重组表皮生长因子治疗宫颈癌放射性皮炎,能提高放射性皮炎治愈率,缩短皮炎愈合时间,减轻患者放疗过程的痛苦,使患者顺利完成放疗过程。

ObjectiveTo study the effect of oxygen therapy combined with recombinant epidermal growth factor on cervical cancer radioactive dermatitis.MethodsFrom October 2013 to October 2015 in Guangxi tumor hospital,70 stage IIIB cervical cancer patients with radioactive dermatitis from intensity modulated radiation therapy（IMRT）were enrolled in the study,35 cases with dermatitis occurring on odd date as the study group and another 35 with dermatitis occurring on even date as the control group.The former were treated with oxygen therapy combined with epidermal growth factor and the latter with recombinant epidermal growth factor alone.The two groups were compared in terms of curative effect,wound healing time and pain.ResultsThe total effective rate of the research group was significantly higher than that of the control group（P0.01）.The healing time of the research group was significantly shorter than that of the control group（P0.001）.ConclusionThe oxygen therapy combined with recombinant epidermal growth factor is more effective in improving the cure rate,shorten healing time of dermatitis,reduce the pains from radiotherapy and help them through the radiotherapy process.