摘要
目的分析我国人群中Egr-1基因在胶质瘤患者中多态性的表达。方法选取231例胶质瘤患者为病例组,121例非肿瘤患者为对照组,应用Taqman技术检测两组患者Egr-1基因多态性,应用SPSS 15.0统计软件对Taqman技术成功检测分型结果进行统计学处理,分析该位点多态性。结果统计学分析结果显示:病例组中T/T+C/C基因型频率、T等位基因频率分别为29.9%、47.6%,均小于对照组的37.2%、52.1%,但差异均无统计学意义(P﹥0.05)。结论 Egr-1基因多态性与胶质瘤的发病风险之间无明显关联。
Objective To analyze the expression of Egr-1 gene polymorphism in Chinese glioma patients. Method 231 cases of gliomas patients and 121 patients of non-cancer patients were analyzed for Egr-1 gene polymorphism by Taq-man technology, SPSS 15.0 was applied to statistically analyze the successful gene classification results. Result The sta-tistical analysis showed that：in glioma group, the frequency of T/T＋C/C and T allele genotype were 29.9%and 47.6%, which were less than those in the control group at 37.2%and 52.1%, respectively, with no statistically significant differ-ence observed （P〉0.05）. Conclusion There is no significant association between Egr1 gene polymorphism and the risk of glioma.
出处
《癌症进展》
2017年第4期393-394,共2页
Oncology Progress
基金
黑龙江省卫生厅资助项目(2011-127)
