摘要
Leber遗传性视神经病变是一种双眼进行性视力下降的遗传性线粒体病。当前治疗主要包括直接增强线粒体功能和阻止氧化损伤。本文将从线粒体鸡尾酒、艾地苯醌、α-三烯酶醌、溴莫尼定、中医中药、基因治疗、限制烟酒及物理疗法7个方面的治疗进展进行综述,进而为治疗Leber遗传性视神经病变提供思路。
Leber＇ s hereditary optic neuropathy （LHON） is an inherited mitochon- drial disorder characterized by bilateral progressive vision loss. Current management includes therapies directed at enhancing mitochondrial function and preventing oxidative damage. This article reviews the progress of treatments from mitochondria cocktail,idebenone, gene therapy, EPI-743, brimonidine, traditional Chinese medicine and physical therapy,providing a new insight in the treatments of LHON.
出处
《眼科新进展》
CAS
北大核心
2017年第7期684-687,共4页
Recent Advances in Ophthalmology
基金
国家自然科学基金(编号:81260149)~~
