晚期肺类癌的诊治进展

Progress in diagnosis and therapy of advanced pulmonary carcinoid

肺类癌是一种罕见低度恶性的肺部神经内分泌肿瘤。不同于其他消化道神经内分泌肿瘤,肺类癌很少引起激素相关的神经内分泌症状。其确诊有赖于病灶的活检,而免疫组织化学染色是病理诊断的重要补充及分级标准。早期肺类癌首选手术治疗。晚期肺类癌的治疗仍面临严峻挑战,且是存在争议、困扰大部分临床医生的主要问题。本文就晚期肺类癌的目前诊治状况及相关进展加以探讨。

Pulmonary carcinoid （PC） is a rare low-grade malignant neuroendocrine tumor. Unlike other neuroendocrine tumors of the digestive tract, PC seldom causes hormone-related neuroendocrine symptoms, and the diagnosis mainly depends on the biopsy of the lesion. Besides, the immunohistochemical staining technique is an important supplement and a grading standard for pathological diagnosis. Surgery is the first choice for the treatment of early PC. However, the therapy of advanced PC which is the main problem perplexing most of clinicians is controversial and still facing severe challenges. Therefore, we will discuss the current progress of the diagnosis and therapy of advanced PC.