嗜酸粒细胞与颅内动脉瘤的相关性

Relationship between eosinophil count and intracranial aneurysm

目的探讨嗜酸粒细胞与颅内动脉瘤(IA)的相关性。方法回顾性分析我院2014年1月至2015年12月住院的79例IA患者和65例对照组的外周血嗜酸粒细胞水平及相关临床资料,应用Logistics回归分析IA形成的相关危险因素。结果与对照组相比,IA患者嗜酸粒细胞、血小板计数明显升高[(0.18±0.12)109/L vs.(0.12±0.09)109/L;(196.44±57.33)109/L vs.(178.80±47.23)109/L,P均<0.05],血小板分布宽度、平均血小板体积则降低[(13.95±3.332)fL vs.(15.30±3.5)fL;(11.02±1.73)fL vs.(11.66±1.31)fL,P均<0.05];多因素Logistics回归分析显示嗜酸粒细胞是IA的独立危险因素。结论嗜酸粒细胞升高是IA形成的独立危险因素。

Objective To assess the relationship between eosinophil count and intracranial aneurysm （IA）. Methods For the retrospective study, we collected data of the count of eosinophils obtained from the peripheral blood samples and other clinical data of 79 patients with IA admitted to our hospital between January 2014 and December 2015 and 65 healthy people as control group. Risk factors for IA were analyzed by multivariate Logistics regression analysis. Results Clinical characteristics were comparable between the two groups （P 〉 0. 05）. Compared with those in the control group, eosinophil and platelet counts in IA group were significantly higher [（0.18±0.12）10^9/L vs. （0.12±0.09）10^9/L; （196.44±57.33）10^9/L vs. （178.80±47.23）10^9/L, respectively; all P〈0. 051, while platelet distribution width （PDW） and mean platelet volume （MPV） were lower [（13.95±3. 332） fL vs. （15.30±3.5）fL; （11.02±1.73）fL vs. （11.66±1.31）fL, respectively; all P〈0.05）. Logistic regression analysis indicated that eosinophil was the independent risk factor for IA. Conclusion Our study demonstrated that increased eosinophil count is the independent risk factor for IA.