三维斑点追踪成像左心室应变指标正常参考范围的Meta分析

Reference range of left ventricular strain measured by three-dimensional speckle-tracking imaging:Meta analysis

目的采用Meta分析评估健康成人的三维斑点追踪成像(3D-STI)左心室整体纵向应变(GLS)、整体环向应变(GCS)、整体径向应变(GRS)、整体面积应变(GAS)的正常参考范围。方法在Embase、Pubmed、Cochrane Library等英文资料库中,检索2016年8月1日前公开发表的关于3D-STI评价左心功能的病例对照研究。按照纳入和排除标准,对文献进行筛查和提取数据。以加权均数差(WMD)及95%可信区间(CI)作为合并统计量,采用的统计分析软件为STATA 12.0。结果最终纳入27项研究,1 552名健康成年被试。GLS的WMD和95%CI为17.80、(16.27,19.33),GCS的WMD和95%CI为24.73、(22.50,26.95),GRS的WMD和95%CI为47.86、(39.52,56.19),GAS的WMD和95%CI为36.17、(34.08,38.26)。结论通过Meta分析确定成人左心室应变指标的正常参考范围,对采用3D-STI评价疾病状态下心脏结构和功能的变化具有一定的指导意义。

Objective To obtain the normal reference ranges of global longitudinal strain （GLS）, global circumferential strain （GCS）, global area strain （GAS） and global radial strain （GRS） of left ventricular in normal adults by three-dimensional speckle tracking imaging （3D-STI） using Meta analysis. Methods Eligible trials which detected global strain of left ventricular in normal subject through 3D-STI were searched in Embase, Pubmed, Cochrane Library database. According to the heterogeneity, parameters of contained studies were analyzed the weighted mean difference （WMD） and 95% confidence interval （CI）. The statistical software was STATA 12.0. Results Totally 1 552 healthy adults from 27 articles were included. Based on the Meta-analysis, the WMD and 95%CI of GLS were 17.80 and （16.27, 19.33）, of GCS were 24.73 and （22.50, 26.95）, of GRS were 47.86 and （39.52, 56.19）, of GAS were 36.17 and （34.08, 38.26）. Conclusion The Meta analysis defines reference range of strains obtained by 3D-STI in healthy adults. Using these parameters of 3D globe strains, a guidance of reference for patient＇s management and therapy selection may be provided.