移植物抗宿主病生物学标志物的研究进展

Research progress in biomarkers of graft versus host disease

异基因造血干细胞移植（allo-HSCT）是某些血液系统肿瘤和部分自身免疫缺陷性疾病唯一有效的治疗手段。然而，移植物抗宿主病（GVHD）是allo-HSCT后最常见并发症之一，也是移植相关死亡的主要原因之一。目前，临床尚缺乏有效预测allo-HSCT后发生GVHD的生物学标志物。笔者从主要组织相容性复合物（MHC）、非人类白细胞抗原（HLA）基因多态性、微小RNA（MiRNA）、细胞生物学标志物、细胞因子、病理学标志物方面，对可能作为预测GVHD发生的生物学标志物进行综述。

Allogeneic hematopoietic stem cell transplantation （allo-HSCT） is the unique effective treatment of certain hematological malignancies and partly autoimmune deficiency diseases. However, graft- versus-host disease （GVHD） is one of the common complications after allo HSCT, and is one of the main causes of death related to transplantation. Currently, we are lack of the effective biomarkers for forecasting GVHD in clinical. So this paper reviews the potential biomarkers that may be used to predict GVHD,which including major histocompatibility complex （ MHC ）, non-human leukocyte antigen （ HLA ） gene polymorphism, microRNA （MiRNA）, cell biology markers, cytokines, pathology markers.