慢性活动性EB病毒感染的研究进展

Research progress of chronic active Epstein-Barr virus infection

机体感染EB病毒（EBV）后，可以表现为持续性或反复发作性发热，肝、脾、淋巴结大，以及肝丙氨酸氨基转移酶水平异常增高等传染性单核细胞增多症（IM）样症状。伴随EBV特异性抗体谱表达与外周血EBV—DNA拷贝数显著增高的EBV感染，称为慢性活动性EB病毒感染（CAEBV）。CAEBV为一种临床少见的致命性疾病，预后凶险，导致的患者病死率极高。目前，CAEBV的发病机制尚未完全阐明，亦无标准治疗方案。笔者拟就CAEBV的发病机制、临床表现、诊断及治疗研究的最新进展进行综述，旨在提高临床医师对CAEBV的认识。

Epstein-Barr virus （EBV） infection is characterized as chronic or recurrent infectious mononucleosis （IM）-like symptoms, such as fever, extensive lymphadenopathy, hepatosplenomegaly and persistent hepatitis. Additionally, the expression of EBV specific antibody spectrum and a significant incrcase of EBV DNA copies are often demonstrated in peripheral blood of patients with chronic active Epstein-Barr virus infection （CAEBV）. CAEBV is a rare fatal disease with poor prognosis and high mortality. The pathogenesis of CAEBV is unknown and there is no standarlized treatment. In order to improve understanding of CAEBV in the clinical work, this article summarizes the pathogenesis, clinical features, diagnose and therapies of CAEBV.