武汉地区54524例孕产妇不规则抗体筛查结果分析

Analysis of irregular antibody screening results of 54 524 pregnant women in Wuhan

目的:观察不规则抗体产生的频率及其特异性,提前为孕产妇选择相应的血制品,以确保输血安全。方法:应用微柱凝胶法对拟备血孕产妇进行不规则抗体筛查并对其进行鉴定。结果:在52 524例被检血清标本中检出不规则抗体阳性者191例,阳性率为0.36%。其中Rh系统48.7%(93/191),MNS系统21.5%(41/191),P系统1.05%(2/191),Lewis系统1.6%(3/191),Kidd系统0.5%(1/191)。结论:孕妇不规则抗体筛查在保证孕妇输血安全及预防和减少新生儿溶血病的发生中有着十分重要的意义,尤其应重视Rh系统和MNS系统不规则抗体筛查。

Objective： To observe the frequency and the specificity of the irregular antibodies, and select the corre- sponding blood products for pregnant women in advance, so as to ensure the safety of transfusion. Method： The irregular antibodies were screened and identified by micro column gel method. Result：Among the 52 524 cases, 191 positive screening results were detected, and the positive rate was 0.36 %. Among them, Rh system accounted for 48. 7% （93/191）, MNS system 22. 5% （43/191）, P system 1.05% （2/191）, Lewis system 1.6% （3/191）, and Kidd system 0. 5% （1/ 191）. Conclusion： Irregular antibodies screening would have very important meaning for pregnant women in transfusion safety , which could reduce and prevent hemolytic disease of the newborn. In particular, we should pay more attention to the irregular antibody screening of Rh system and MNS system.