MicroRNA在软组织肉瘤异常表达与生物标记物的研究进展

Abnormal microRNA expression and its potential as a biomarker in soft tissue sarcoma

软组织肉瘤是一种高度异质性来源于间充质组织的恶性肿瘤。由于其组织学亚型较多,临床和组织病理学的不确定性,对于目前的诊断和治疗都是很棘手问题。其中一个重要的临床问题是缺乏有用的生物标志物;因此,可用于检测肿瘤的生物标志物的发现对化疗或放疗的反应可能有助于临床医生提供更有效的临床管理。microRNA在软组织肉瘤中研究提供了解决问题线索。软组织肉瘤中差异microRNA和患者血清中的循环microRNA等证据发现潜在的加速了向临床应用的转变,这无疑给根除软组织肉瘤带来了新的希望。

Soft tissue sarcomas are a highly heterogeneous group of malignant tumors that originate from mesenchymal tissues. They have a large variety in histological subtypes and ambiguous clinical and histopathological characteristics, which lead to great challenges in their diagnosis and therapy. One important clinical challenge is a lack of useful biomarkers. Identification of the biomarkers that can be used to detect tumor responses to chemotherapy or radiotherapy may provide more effective clinical management approaches for clinicians. One potential solution is based on the research on microRNA in soft tissue sarcomas. The evidence of microRNA in tumor tissues and circulating microRNA in patients＇ serum promotes the potential application of microRNA as a clinical biomarker, giving us new hope for curing soft tissue sarcoma.