摘要
巨噬细胞是单核吞噬细胞系统晚期分化细胞,是机体重要的免疫细胞,在维持机体稳态中发挥重要作用。巨噬细胞在不同微环境中功能特性不同,呈现明显异质性。巨噬细胞按照其表型和分泌的细胞因子可分为两大类,即经典活化型巨噬细胞(M1型)和替代活化型巨噬细胞(M2型)。巨噬细胞极化在感染、肿瘤、代谢和免疫等多种疾病的发生发展中发挥重要作用。本文就巨噬细胞极化的研究进展作一综述。
Macrophages, an important component of innate immune cells, are members of the mono- nuclear phagocyte system which play key roles in maintaining homeostasis. Macrophages can differentiate into a pro-inflammatory classically activated subtype （M1） and an anti-inflammatory alternatively activated subtype （M2） according to their microenvironment. Macrophage polarization play an important role in the occurrence of infection, tumor, metabolic, and immunology diseases. We will discuss the re- search progress of macrophage polarization.
出处
《中华临床免疫和变态反应杂志》
2017年第2期161-165,共5页
Chinese Journal of Allergy & Clinical Immunology
基金
国家自然科学基金(81571598)
关键词
单核细胞
巨噬细胞
极化
monocytes
macrophages
polarization
