摘要
1-磷酸鞘氨醇受体是1-磷酸鞘氨醇在细胞内发挥作用的重要靶点,包括5种亚型,广泛存在于包括心血管系统在内的各系统。近年来,许多研究发现1-磷酸鞘氨醇受体3在血管舒张、血管屏障功能、缺血再灌注损伤和动脉粥样硬化等过程中具有重要的生物学作用。现就1-磷酸鞘氨醇受体3在心血管系统中的作用及其机制做一综述。
Sphingosine-1-phosphate receptors are important targets for sphingosine-1-phosphate to play roles in cells, and five subtypes of sphingosine-1-phosphate receptors are included, which are widely expressed in all systems inclu-ding cardiovascular system. The receptors have various important biological effects on vasodilatation, vascular endothelial barrier function, ischemia reperfusion injury, atherosclerosis, etc. This paper makes a review on roles and mechanisms of sphingosine-1-phosphate receptor 3 in cardiovascular system.
出处
《中国动脉硬化杂志》
CAS
北大核心
2017年第7期741-745,共5页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金资助项目(81370372)
关键词
1-磷酸鞘氨醇受体3
G蛋白偶联受体
心血管系统
Sphingosine-l-phosphate receptor 3
G protein-coupled receptor
Cardiovascular system
