玉环县海岛居民饮酒量与2型糖尿病及糖调节受损的关系研究

The association of alcohol consumption with type 2 diabetes and impaired glucose regulation among residents on islands of Yuhuan county

目的探索海岛居民饮酒情况与2型糖尿病(type 2 diabetes mellitus,T2DM)及糖调节受损(impaired glucose regulation,IGR)的关系。方法 2012年6~12月,本研究采用整群随机抽样方法抽取浙江省玉环县3个乡镇,利用流行病学调查问卷进行面对面调查。结果 26 450人中,轻度、中度和重度饮酒率分别为7.33%、2.82%和4.88%。饮酒量与IGR和T2DM患病率呈J型关系,轻度饮酒者的IGR和T2DM患病率最低,分别为16.14%和11.91%。在调整其他可能的影响因素后,不饮酒、中度和重度饮酒患T2DM风险分别是轻度饮酒的1.00(0.84~1.18)、1.12(0.86~1.45)和1.17(0.94~1.45)倍,患IGR风险分别是轻度饮酒的0.94(0.82~1.09)、1.16(0.93~1.46)和1.29(1.07~1.56)倍。结论饮酒量与IGR和T2DM患病率之间存在J型关系,重度饮酒可能增加IGR的患病风险。

Objective To explore the association of alcohol consumption with impaired glucose regulation（IGR）and type 2 diabetes mellitus（T2DM）among residents on islands of Yuhuan county. Methods A face-to-face questionnaire survey was conducted among residents randomly selected using cluster sampling method from islands of 3 Yuhuan counties during June to December,2012.Participants were divided into four groups,including non-alcohol consumption,light alcohol consumption,moderate alcohol consumption,and heavy alcohol consumption. Results Total 26 450 residents were surveyed.The prevalence of light,moderate and heavy alcohol consumption were 7.33%,2.82% and 4.88%,respectively.The J-shape curve was observed between alcohol consumption and prevalence of IGR or T2DM with the lowest prevalence in residents with in moderate alcohol consumption（16.14% and 11.91%,respectively）.After adjusted for covariates,compared to participants with light alcohol consumption,the adjusted odds ratio and its 95% confidential interval of no,moderate and heavy alcohol consumption were 0.94（0.82-1.09）,1.16（0.93-1.46）and 1.29（1.07-1.56）for IGR,and were 1.00（0.84-1.18）,1.12（0.86-1.45）and 1.17（0.94-1.45）for T2DM,respectively. Conclusions The J-shape relationship is observed between alcohol consumption and the incidences of IGR and T2DM,and heavy alcohol consumption may increase the risk of IGR.