盐酸二甲双胍片联合阿卡波糖胶囊治疗75例2型糖尿病的临床分析

Clinical analysis of metformin hydrochloride tablets combined with acarbose capsules in the treatment of 75 cases of type 2 didabetic mellitus

目的评价盐酸二甲双胍片联合阿卡波糖胶囊治疗2型糖尿病的疗效。方法 150例2型糖尿病患者,随机分为观察组和对照组,各75例。对照组采用盐酸二甲双胍片治疗,观察组采用盐酸二甲双胍片联合阿卡波糖胶囊治疗。比较两组患者的空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(GHb A1c)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、体质量指数(BMI)水平。结果治疗后,观察组患者的FBG为(5.32±2.15)mmol/L、2 h PG为(7.79±1.52)mmol/L、GHb A1c为(6.63±1.37)%,均低于对照组的(6.42±2.43)mmol/L、(8.65±1.87)mmol/L、(7.51±1.85)%,差异均有统计学意义(P<0.01)。治疗后,观察组患者的TG为(1.54±0.65)mmol/L、LDL-C为(2.72±0.97)mmol/L,均低于对照组的(1.93±0.84)mmol/L、(3.34±1.12)mmol/L,差异均有统计学意义(P<0.01)。观察组的BMI水平(24.15±5.75)kg/m^2和对照组(25.43±6.19)kg/m^2比较,差异无统计学意义(P>0.05)。结论盐酸二甲双胍片联合阿卡波糖胶囊治疗2型糖尿病的疗效显著,可以达到降低、稳定患者血糖的效果。

Objective To evaluate the curative effect of metformin hydrochloride tablets combined with acarbose capsules in the treatment of type 2 didabetic mellitus. Methods A total of 150 type 2 diabetic mellitus patients were randomly divided into observation group and control group, with 75 cases in each group. The control group received metformin hydrochloride tablets for treatment, and the observation group received metformin hydrochloride tablets combined with acarbose capsules for treatment. Comparison were made on fasting blood- glucose （FBG）, 2 h postprandial glucose （2 h PG）, glycosylated hemoglobin （GHbAlc）, triglyceride （TG）, low density lipoprotein cholesterin （LDL-C） and body mass index （BMI） level in two groups. Results After treatment, the observation group had FBG as （5.32 ± 2.15） mmol/L, 2 h PG as （7.79 ± 1.52） retool/L, GHbAlc as （6.63 ± 1.37）%, which were all lower than （6.42 ± 2.43） mmol/L, （8.65 ± 1.87） mmol/L and （7.51 ± 1.85）% in the control group. Their difference had statistical significance （P〈0.01）. After treatment, the observation group had TG as （1.54 ± 0.65） mmol/L, LDL-C as （2.72 ± 0.97） nunol/L, which were all lower than （1.93 ± 0.84） mmol/L and （3.34 ± 1.12） mmol/L in the control group, and their difference had statistical significance （P〈0.01）. The observation group had no statistically significant difference in BMI level as （24.15 ±5.75） kg/m^2 comparing with （25.43 ±6.19） kg/m^2 in the control group （/）〉0.05）. Conclusion Combination of mefformin hydrochloride tablets and acarbose capsules shows significant curative effect and it has effect of decreasing and stabling blood glucose.