血清胱抑素C与缺血性卒中患者颅内外动脉狭窄的关系

Interrelation between the serum cystatin C and cerebral artery stenosis in patiens with cerebral ischemic stroke

目的探讨缺血性卒中患者胱抑素C(cystatin C,Cys C)与脑动脉粥样硬化性狭窄的关系。方法应用荷兰Philips公司生产的FD-20C型臂血管造影系统,对299例缺血性卒中患者进行全脑血管造影及血浆Cys C检测,根据Cys C检测水平,分为对照组(Cys C正常)139例患者与异常组(Cys C异常)160例患者,比较其全脑血管造影结果。结果正常组(对照组)与异常组(病例组)脑动脉狭窄程度差异有统计学意义(χ~2=16.94,P<0.05);异常组中颅内外动脉中重度狭窄和闭塞的比率显著升高,且以无侧支循环代偿及弥漫性病变为主;随着Cys C的升高,脑动脉狭窄程度逐渐加重。结论 Cys C是缺血性脑卒中患者脑动脉粥样硬化性狭窄的一种危险因素,脑血管狭窄与Cys C升高有关,Cys C在一定程度上反映脑血管狭窄程度。

Objective To explore the relationship between the cystatin C and cerebral atherosclerotic stenosis in patients with cerebral ischemic stroke. Methods For all 299 cases of ischemic cerebrovascular patients,cerebral angiography was performed by FD-20 C-arm angiography system which produced by the Dutch company Philips,and serum Cys C was detected. According to the levels of Cys C,all patients were divided into normal Cys C group （control group,n=139） and high Cys C group （case group,n~ 160） ,and then we analyze the results of cerebral angiography between two groups. Results The differences of cere- bral artery stenosis between the control group and case group were statistically; significant {X2= 16.94, P〈0.05）. There were more cases of moderate-severe cerebral artery stenosis and occlusion in the case group than in the control group. The majority of vascular involvement in the ease group was diffuse without collateral circulation. With the increase of Cys C, the cerebral artery stenosis aggravated gradually. Conclusion Cys C may be a risk factor for cerebral artery stenosis in ischemic cerebrovascular disease, cerebral vascular stenosis is related with Cys C, which can reflect the severity of cerebral artery stenosis to some extent.