胰腺再生性基因Reg3研究进展

Research Progress on Pancreas Regeneration Gene Reg3

胰腺再生性基因(Reg)主要在胃肠组织及损伤再生性胰腺组织中高表达,是能够促进胰岛β细胞等组织细胞再生的基因。近些年关于Reg的研究主要集中在Reg各种亚型的基因结构,及其在糖尿病、胃肠道癌症、炎症和抗菌中发挥的作用和相关机制方面。在Reg的各种亚型中,RegⅢ(Reg3)作用更为突出,有望成为治疗这些疾病的有效靶点。基于Reg3与多种疾病的关系,有学者探索了Reg3[人源REG3A,小鼠Reg3γ(Reg3g)]与1型糖尿病、胰腺炎介导的癌变之间的关联及机制,以及所涉及的免疫功能的改变。该文综述关于Reg3的系列研究及其作为药物治疗靶点的可行性。

Objective Regenerating genes express mainly in gastrointestinal tissues and the injured regenerating pancreatic tissues,which can promote the regeneration of pancreatic p cells and other tissue cells.In recent years,researches on Reg family mainly involved the gene structure of various subtypes of Reg, and its role in diabetes, gastrointestinal cancer, in!lammation,anti-microbial and the related mechanisms.Among the various subtypes of Reg,regenerating geneM（Reg3） plays a particularly crucial role in these diseases.Therefore,Reg3 is a promising target for the treatment of these diseases.Based on the relationships of Reg3 with a variety of diseases, our group devote to the role of Reg3 [human REG3A, and mouse Reg3Y （Reg3g） ] in type 1 diabetes,inflammation-linked pancreatic carcinogenesis,and the immunological changes participated in these processes.Hence,this review- will summarize serial studies on Reg3 and the feasibility of it as drug targets.