类风湿关节炎患者抗环瓜氨酸肽抗体水平与心血管事件的关系研究

Study on the Relationship between Anti-cyclic Citrullinated Peptide Antibody Level and Cardiovascular Events in Patients with Rheumatoid Arthritis

目的:研究类风湿关节炎患者抗环瓜氨酸肽抗体水平与心血管事件的关系。方法:选取某院2015年6月~2016年6月81例类风湿关节炎患者为研究对象,根据心血管事件发生情况,将纳入患者分为心血管病变组和无心血管病变组,心血管病变组28例,无心血管病变组53例,比较抗环瓜氨酸肽抗体水平。结果:心血管病变组的抗环瓜氨酸肽抗体水平为(673.28±319.55)RU/ml,显著高于无心血管病变组的(224.29±78.12)RU/ml(P<0.05)。结论:类风湿关节炎患者抗环瓜氨酸肽抗体水平越高,患者发生心血管事件的风险越高,抗环瓜氨酸肽抗体对类风湿关节炎患者心血管事件的发生具有重要的提示作用。

Objective：To study the relationship between anti-cyclic citrullinated peptide antibody and cardiovascular events in patients with rheumatoid arthritis.Methods：A total of 81 patients with rheumatoid arthritis were enrolled in this study from June 2015 to June 2016.According to the incidence of cardiovascular events,patients were divided into two groups：cardiovascular disease group（28 cases）and non-cardiovascular disease group（53 cases）.Then compare anti-cyclic citrullinated peptide antibody level of the two groups.Results：The anti-cyclic citrullinated peptide antibody level in the cardiovascular disease group was（673.28±319.55）RU/ml significantly higher than that in the non-cardiovascular group（224.29±78.12）RU/ml（P〈0.05）.Conclusion：The higher the level of anti-cyclic citrullinated peptide antibody in patients with rheumatoid arthritis is,the higher the risk of cardiovascular events is.The anti-cyclic citrullinated peptide antibody has important implications for the occurrence of cardiovascular events in patients with rheumatoid arthritis effect.