普瑞巴林结合针灸和综合康复训练对腰椎间盘突出症患者的临床疗效研究

Clinical study on the effects of pregabalin coupled with acupuncture and rehabilitation training on lumbar disc herniation

目的研究普瑞巴林结合针灸以及系统康复训练治疗腰椎间盘突出症的临床疗效。方法经CT或磁共振成像(MRI)确诊,采用随机配对的方式分为普瑞巴林+针灸+综合康复治疗组(A组)、美洛昔康+针灸+综合康复治疗组(B组)、常规康复治疗组(C组)作为对照组。治疗前后采用VAS评分、ODI指数评分,观察3组患者治疗前后腰腿部疼痛麻木情况。结果 3组患者的ODI指数、疼痛和麻木与干预前比较差异无统计学意义(P>0.05),14 d后和1个月随访均得到改善(P<0.05),其中A组在干预后ODI指数以及疼痛和麻木症状与其余2组比较改善明显,差异有统计学意义(P<0.05)。结论普瑞巴林结合针灸以及系统康复治疗对腰椎间盘突出症的临床疗效好,值得推广。

Objective To investigate the effects of pregabalin coupled with acupuncture and rehabilitation training on lumbar disc herniation （LDH）. Methods Following diagnosis and confirmation by CT or MRI, 60 patients with LDH were randomly divided into 3 groups group A, the pregabalin plus acupuncture and rehabilitation training group; group B, the meloxicam plus acupuncture and rehabilitation training group; and group C, the routine rehabilitation training group or the control group. Scores of VAS and ODI were evaluated, and lumbocrural pain and numbness in the patients of the 3 groups were closely observed before and after treatment. Results Before intervention, there were no statistical differences in ODI, pain and numbness indexes, when comparisons were made between the patients of the 3 groups （P 〈0. 05） . Medical follow-ups 14 days and 1 month after intervention indicated that symptoms of the patients were all improved, and ODI as well as pain and numbness indexes of Group A were more significantly improved, when com-pared with those of the other 2 groups. Statistical significance could be seen, when comparisons were made between the 3 groups （P 〈 0. 05 ）. Conclusion Pregabalin coupled with acupuncture and rehabilitation training could produce better therapeutic effects on lumbar disc herniation. For this reason, it was worth further clinical extension.