益气养阴活血法治疗糖尿病肾病Ⅲ期30例

Treatment of 30 Cases of Diabetic Nephropathy Stage III with Supplementing Qi and Nourishing Yin and Activating Blood Circulation

目的:探讨益气养阴活血法治疗糖尿病肾病的临床效果。方法:选择糖尿病肾病Ⅲ期辨证为气阴两虚兼血瘀证患者60例,随机分为观察组和对照组,两组各30例。对照组给予基础治疗加口服厄贝沙坦,观察组给予口服中药益气养阴活血方,两组均治疗8周,观察比较两组疗效、治疗前后血糖、糖化血红蛋白、尿白蛋白排泄率、总胆固醇、甘油三酯、血液流变学及中医症候积分等。结果:两组临床及中医症候有效率比较,观察组优于对照组(P<0.05);两组治疗前后空腹血糖、糖化血红蛋白、尿白蛋白排泄率、总胆固醇、甘油三酯及血液流变学等指标均有明显下降(P<0.05),两组治疗后UAER、空腹血糖、糖化血红蛋白、血液流变学指标比较有显著性差异(P<0.05);在改善中医症候积分方面,观察组优于对照组(P<0.05)。结论:益气养阴活血法治疗气阴两虚兼血瘀型糖尿病肾病临床效果满意。

Objective ： To observe clinical effect of Supplementing Qi and Nourishing Yin and Activating Blood Circulation on Diabetic Nephropathy（ DN） stage IH. Methods ： Sixty DN patients with the syndrome of blood - stasis and Qi - yin - deficient were randomly divided into two groups. AH were treated with basical treatment. The treatment group with 30 cases, treated by Supplementing Qi and Nourishing Yin and Activating Blood Circulation, and the con-trol group with 30 cases,treated by irbesartan. Duration of 8weeksJ treatment, urine albumin excretion rate（UAER） ,fasting blood glucose（FBG） , glyco-sylated hemoglobin （ HbAl） , total cholesterol（TC） triglyceride（TG） , hemorheological parameters and Traditional Chinese Medical（TCM） syndrome scores were observed to evaluate efficacy of the theraphy. Results： The total effective rate was higher in the treatment group than that in the control group（P 〈 0.05）. The changes of urine albumin excretionrate（ UAER） ,fastingbloodglucose（ FBG） , glycosylated hemoglobin（ HbAl） , total cholesterol（ TC ） , triglyc-eride （TG） ,hemorheological parameters were decreased apparently after 8 - weeks treatment（P 〈0.05） ,and the reduction of treatment group was more significant than the control group（P 〈0.05） ,and the results were statistically significant. In the TCM syndrome score the treatment group was better than the control group, and it had statistical significance. Conclusion ： The method of Supplementing Qi and nourishing yin and activating blood circulation is ef-fective in the treatment of diabetic nephropathy with Qi and yin deficiency combined with blood stasis.