广西壮族自治区白裤瑶族居民高同型半胱氨酸血症患病情况及其影响因素调查研究

Prevalence and Influencing Factors of Hyperhomocysteinemia in Baiku Yao Nationality Residents in Guangxi

目的调查广西壮族自治区白裤瑶族居民高同型半胱氨酸血症(HHcy)患病情况,分析其影响因素。方法采用分层整群随机抽样方法调查2015—2016年于广西壮族自治区大石山区居住时间>6个月的白裤瑶族居民600例,比较不同临床特征居民HHcy患病率,广西壮族自治区白裤瑶族居民HHcy的影响因素分析采用多因素Logistic回归分析。结果本组广西壮族自治区白裤瑶族居民HHcy患病率为35.7%(214/600)。不同性别、不同年龄段、是否吸烟、是否饮酒、有无高血压的广西壮族自治区白裤瑶族居民HHcy患病率比较,差异有统计学意义(P<0.05);有无糖尿病及不同BMI、TC和TG的广西壮族自治区白裤瑶族居民HHcy患病率比较,差异无统计学意义(P>0.05)。多因素Logistic回归分析结果显示,性别[OR=2.898,95%CI(1.090,7.706)]、年龄[OR=2.942,95%CI(1.077,8.037)]、饮酒[OR=4.540,95%CI(1.027,17.409)]、高血压[OR=4.221,95%CI(0.844,21.098)]是广西壮族自治区白裤瑶族居民HHcy的影响因素(P<0.05)。结论广西壮族自治区白裤瑶族居民HHcy患病率较高,而性别、年龄、饮酒、高血压是广西壮族自治区白裤瑶族居民HHcy的影响因素。

Objective To investigate the prevalence and influencing factors of hyperhomocysteinemia in Baiku Yao Nationality residents in Guangxi. Methods A total of 600 Baiku Yao Nationality residents with dwelling time over 6 months were selected in Dashi Mountainous Area in Guangxi from 2015 to 2016 according to stratified random clustersampling method, and they were divided into A group （with hyperhomocysteinemia, n = 214） and B group （without hyperhomocysteinemia, n = 386） according to the incidence of hyperhomocysteinemia. Prevalence rate of hyperhomocysteinemia was compared in the residents with different clinical features, and influencing factors of hyperhomocysteinemia in Baiku Yao Nationality residents in Guangxi were analyzed by multivariate Logistic regression analysis. Results The prevalence rate of hyperhomocysteinemia was 35. 7% （ 214/ 600）. There were statistically significant differences of prevalence rate of hyperhomocysteinemia was found in Baiku Yao Nationality residents with different gender, with different age, with smoking or not, with drinking or not, complicated with hypertension or not （ P 〈 0. 05 ） , while no statistically significant differences of prevalence rate of hyperhomocysteinemia in Baiku Yao Nationality residents complicated with diabetes or not, with different BMI, with different TC, with different TG （ P 〉0. 05） . Multivariate Logistic regression analysis results showed that, gender [ OR = 2. 898 , 95% Cl （1. 077 , 8. 037 ） ] , age [0^=2.942, 95%CI （0.727, 11.899）], drinking [0^=4.540, 95% Cl （1 .0 8 4 , 1 9 .0 2 5 ） ] and hypertension [OR =4. 221, 95% Cl （ 1. 027 , 17. 409 ）〕were influencing factors of hyperhomocysteinemia in Baiku Yao Nationality in Guangxi （ P〈0.05）. Conclusion The prevalence rate of hyperhomocysteinemia is relatively high in Baiku Yao Nationality residents in Guangxi, gender, age, drinking and hypertension are the influencing factors of hyperhomocysteinemia.