血清透明质酸的测定在肝纤维化诊断中的应用

目的分析血清透明质酸（HA）的测定对肝纤维化的渗断价值。方法选取121例处于不同严重程度的病毒性肝炎患者的标本,采用放射免疫法（RIA）测定血清中的HA水平，比较各组病毒性肝炎之间及健康献血者血清HA差异．结合病理结果进行分析。结果血清HA水平在肝炎锌组及肝硬化不同病理分期的差异均有统计学意义（P〈0．01），在慢性肝炎中度患者明融升高，以慢性肝炎重度、肝硬化者为最高，其升尚程度与肝纤维化及肝病，严重程度量正相关。结论动态测定血清HA水平，可作为反映慢性肝病肝纤维化严再程度和预后的指标。

Objective To explore the diagnostic value of the measuration of hyaluronic acid （HA） in the diagnosis of liver fibrosis. Methods RIA was used to detect the level of HA in serum of 121 patients with virus hepatitis. We analyzed the data combined with the pathological alteration. Results The level of HA in serum of patients with medium chronic hepatitis obviously heightened, and the HA of severe chronic hepatitis and hepatocirrhosis were the highest. Differences between these three groups and other groups were SiR nificant （P〈0.05）. The increased degree was positively related to tbe degree of hepatic fibrosis and severity of liver disease. Conclu- sion Detecting the level of HA in serum dynamicly can reflect the fibrosis degree of chronic liver disease and it＇s prognosis.