抗生素联合糖皮质激素治疗老年慢性阻塞性肺气肿的临床效果分析

目的分析抗生素联合糖皮质激素治疗老年慢性阻塞性肺气肿的临床效果及体会。方法回顾性分析97例老年慢性阻塞性肺气肿患者的临床资料，将其随机分为观察组和对照组，其中观察组49例，对照组48例，观察组采用单纯的抗生素进行治疗，观察组采用抗生素联合糖皮质激素进行治疗，比较两组患者的临床效果及肺功能指标。结果观察组患者中达到显效标准者24例，有效者21例，余者4例无效，观察组临床总有效率为91．84％；对照组患者达到显效标准者18例，有效者19例．余者11例无效，对照组临床总有效率为77．08％．观察组临床总有效率显著高于对照组（P〈0．05）。观察组患者的TV、MVV、FVC、FEV1、FEV1％等肺功能指标均显著优于对照组，差异具统计学意义（P〈0．05）。结论针刘。老年慢性阻塞性肺气肿患者采用抗生素联合糖皮质激素进行治疗临床效果显著优于单纯抗生素治疗，具有较高的临床应用价值。

Objective to analyze the clinical effect and experience of the treatment of senile chronic obstructive pulmonary emphyse- ma with the combination of antibiotics and glucocorticoid. Methods retrospective analysis of the clinical data of 97 cases of elderly pa- tients with chronic obstructive pulmonary emphysema, which were randomly divided into observation group and control group, 49 cases in the observation group, 48 cases in the control group, the observation group received antibiotic treatment, observation group were treated with antibiotics combined with glucocorticoid treatment, were compared between the two groups the clinical efficacy and lung function index. Results the patients in the observation group reached the standard effective 24 cases, effective in 21 cases, more than 4 cases invalid, the total efficiency of the observation group was 91.84% 18 patients in control group were reached the standard, effec- tive in 19 cases, more than 11 cases were invalid. The total effective rate of the control group was 77.08%, the concept of the clinical observation group total effective rate was significantly higher than that of the control group （P〈0. 05）. The observation group of pa- tients with TV, MVV, FVC, FEVI. FEV1 % and other pulmonary function indexes were significantly better than the control group, the difference was statistically significant （P〈0.05）. Conclusion in the elderly patients with chronic obstructive pulmonary emphyse- ma combined with the use of antibiotics in the treatment of the clinical effect is significantly better than the simple antibiotic treatment, has a high clinical value.