1例利奈唑胺致MRSA感染患者血小板减少的病例分析

Analysis of Thrombocytopenia in a Patient with MRSA Infection Induced by Linezolid

目的:探讨耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus,MRSA)感染在特殊情况下的药物选择及不良反应监测,以提高医疗质量及改善患者预后。方法:回顾性分析一例法洛四联症基础疾病患者MRSA感染性心内膜炎合并肺部感染的诊疗资料。结果:一例患有法洛四联症基础疾病的MRSA感染性心内膜炎合并肺部感染患者,先后给予注射用盐酸万古霉素、盐酸左氧氟沙星、利奈唑胺注射液抗感染治疗,治疗过程中出现血小板持续下降,临床药师分析其原因与利奈唑胺相关,调整用药方案,患者好转出院。结论:临床药师必须深入临床,掌握患者病情、监测相关指标,面对可能的不良反应,及时查阅文献,结合患者情况科学评判,解决临床实际问题。

Objective：To investigate the option of the drug and the adverse drug reaction in specific condition with MRSA infection and promote the quality of medical care and the prognosis of patients.Methods：Retrospectively analyzing a case tetralogy of fallot with infectious endocarditis induced by MRSA and pulmonary infection.Results：The platelet continuously decreased during the anti-infection treatment with the vancomycin hydrochloride,levofloxacin hydrochloride and linezolid,which is linked with the linezolid.The patient was discharged from the hospital after changing the drug programs.Conclusion：In order to solve the clinical disease,the clinical pharmacists must master the patient’s condition and monitor the related index.The clinical pharmacists need to review the relevant literature and judge the problem based on the specific condition when they face to the possible adverse reaction.