不同性别冠心病患者体内胆固醇水平差异性研究

Study on the difference of cholesterol level in different gender patients with coronary heart disease

[目的]研究延边地区不同性别冠心病患者合并其他危险因素或疾病时体内胆固醇水平的差异性.[方法]选择2014年4月至2015年7月间在延边大学附属医院就诊的517例冠心病患者临床资料,比较分析不同性别冠心病患者合并其他危险因素或疾病时的体内胆固醇水平.[结果]女性冠心病患者的年龄、胆固醇(TC)、高密度脂蛋白(HDL)及低密度脂蛋白(LDL)水平均显著高于男性(P<0.05),女性饮酒、高血压、脑梗塞、高CHO血症、高三酰甘油(TG)血症及低HDL血症比例均显著高于男性(P<0.05),男性吸烟比例高于女性(P<0.001);冠心病患者合并低HDL血症时,男性患高TC血症的风险是女性的1.56倍(95%CI:1.741~17.438),冠心病患者合并脑梗塞时,女性患高TC血症的风险是男性的1.48倍(95%CI:2.710~23.732).[结论]不同性别冠心病患者在心血管疾病的易感性上存在差异,且合并其他危险因素或疾病时体内胆固醇水平具有差异性.

OBJECTIVE To study the difference of cholesterol level in different gender patients with coronary heart disease（CHD）combined with other risk factors or diseases in Yanbian area.METHODS Clinical data of 517 patients with CHD in Yanbian University Affiliated Hospital from April 2014 to July 2015 were collected.The levels of cholesterol in patients with CHD combined with different risk factors or diseases were compared and analyzed.RESULTS Age,the levels of total cholesterol（TC）,high density lipoprotein（HDL）and low density lipoprotein（LDL）of females with CHD were significantly higher than those of males（P 〈0.05）.The ratios of alcohol consumption,hypertension,cerebral infarction,hypercholesterolemia,hypertriglyceridemia and low HDL in females were significantly higher than those in males（P〈0.05）.The rate of male smoking was higher than that of female（P〈0.001）.Male＇s risk of hypercholesterolemia was 1.56 times as much as female in the patients with CHD combined with low HDL level（95%CI：1.741-17.438）.The risk of females suffering from hypercholesterolemia was 1.48 times of the males in patients with CHD combined with cerebral infarction（95% CI：2.710-23.732）.CONCLUSION There were differences on the susceptibility of cardiovascular disease in the different gender patients with CHD,and the cholesterol level was different when combined with other risk factors or diseases.