地佐辛联合山莨菪碱治疗输尿管结石460例疗效分析

Effect Analysis of Dezocine Combined with Anisodamine to Treat Ureteral Calculi

目的探讨地佐辛联合山莨菪碱治疗输尿管结石的临床效果。方法选择2015年6月—2016年6月在该院治疗的460例输尿管结石患者,随机分为观察组和对照组各230例,观察组应用地佐辛联合山莨菪碱治疗,对照组应用盐酸哌替啶加山莨菪碱治疗,比较两组疗效、疼痛缓解情况、排石时间及不良反应。结果观察组治疗总有效率为90.0%(207/230),对照组为82.6%(190/230),两组比较差异有统计学意义(P<0.05);观察组疼痛缓解总有效率为90.0%(207/230),对照组为76.1%(175/230),两组比较差异有统计学意义(P<0.05);观察组患者排石时间平均为7 d,对照组平均为10 d,差异有统计学意义(P<0.05);观察组不良反应发生率为9.1%(21/230),对照组为10.0%(23/230),差异无统计学意义(P>0.05)。结论地佐辛联合山莨菪碱治疗输尿管结石效果显著,而且不良反应少,值得在临床更多应用。

Objective Explore the clinical effect of dezocine combined with anisodamine to treat ureteral calculi.Methods Select 460 patients that treated in our hospital from June 2015 to June 2016 and randomly divided into observation group and control group with 230 patients in each group,the observation were treated with dezocine and anisodamine,the control group were treated with pethidine and anisodamine,compared the treat effect,pain relief,calculi discharge time and adverse reaction of two groups. Results Total effect of the observation group was 90.0%（207/230）,which of the control group was 82.6%（190/230）,the difference had statistical significance（P〈0.05）; total effect of pain relied in the observation group was 90.0%（207/230）,which of the control group was76.1%（175/230）,the difference had statistical significance（P〈0.05）; average calculi discharge time of the observation group was 7 days,which of the control groups was 10 days,the difference was statistical significant（P〈0.05）; adverse reaction rate of the observation group was 9.1%（21/230）,which of the control group was 10.0%（23/230）,there was no statistical significant（P〉0.05）.Conclusion The effect was remarkable by using dezocine combined with anisodamine to treat ureteral calculi,while the adverse reaction was little and can be more used in clinic.