多索茶碱与噻托溴铵粉联合治疗对慢阻肺患者肺功能的影响

Discussion Doxofylline with Tiotropium Powder on Iung Function in Patients with COPD Combination Therapy

目的探究多索茶碱联合噻托溴铵粉用于慢性阻塞性肺疾病对于患者肺功能的影响。方法选取2014年1月—2015年1月接诊的慢性阻塞性肺疾病患者100例,随机分成两组,各50例,对照组:单纯多索茶碱治疗,研究组:在对照组基础上联合噻托溴铵粉,对比临床疗效及肺功能指标。结果研究组[FEV1(2.39±0.9)L;FVC(2.49±0.2)L;FEV1/FVC(62.42±9.84)%]肺功能指标改善情况较对照组[(FEV1(1.93±0.57)L;FVC(2.26±0.36)L;FEV1/FVC(53.25±6.28)%]好,同时研究组(92.00%)临床总有效率显著高于对照组(78.00%),差异有统计学意义(P<0.05)。结论多索茶碱联合噻托溴铵粉治疗,能够显著改善慢性阻塞性肺疾病患者的肺功能,同时还能有效提高临床疗效,可供临床参考。

Objective To explore joint Doxofylline tiotropium powder used to influence lung function in patients with chronic obstructive pulmonary disease. Methods January 2014 to January 2015 admissions of patients with chronic obstructive pulmonary disease 100 cases were randomly divided into two groups,50 patients in the control groups： simple Doxofylline treatment,research groups： the control group basis joint tiotropium powder,comparing the efficacy and lung function. Results The Study Group [（FEV1（2.39 ± 0.9）L; FVC（2.49 ± 0.25）L;FEV1/FVC（62.42 ± 9.84）% ] improvements in lung function compared with the control group [FEV1（1.93 ± 0.57）L; FVC（2.26 ± 0.36）L; FEV1/FVC（53.25± 6.28）%] is good,while the study group（92.00%） clinical total effective rate was significantly higher（78.00%）,the difference by statistical analysis showed that there were significant（P 〈0.05）. Conclusion Doxofylline joint tiotropium powder treatment can significantly improve patients’ lung function in chronic obstructive pulmonary disease,but also can effectively improve the clinical efficacy,for clinical reference.