亲属活体肾移植术后血肌酐升高影响因素分析

Analysis of Influencing Factors of Serum Creatinine Level after Living Related Kidney Transplantation

目的探讨亲属活体肾移植术后不同阶段血肌酐升高的危险因素。方法收集2012年8月—2014年8月期间在郑州人民医院器官移植科行亲属活体肾移植术患者120例的临床资料,以本院血肌酐值>133μmol/L为血肌酐升高标准,排除急性排斥反应、急性CNI类药物中毒、肺部感染、输尿管梗阻/返流、移植肾肾血管狭窄及药物浓度偏高或偏低等可导致肾功能损害的因素,采用SPSS 13.0统计软件Logistic回归模型对患者肾移植术后6、12、24个月血肌酐升高的因素进行分析。结果多因素分析提示:供体年龄是影响患者肾移植术后6个月血肌酐升高的独立危险因素,其优势比(OR)=1.118。供体年龄,受体血清甘油三酯(TG),受体体重指数(BMI)是影响患者肾移植术后12个月血肌酐升高的独立危险因素,其OR值分别为0.931、0.264、0.720。供体年龄,受体收缩压,受体BMI是影响患者肾移植术后24个月血肌酐升高的独立危险因素,其OR值分别为0.935、1.061、0.787。结论供体年龄是患者肾移植术后6、12、24个月血肌酐升高的独立危险因素;此外,肥胖也是影响患者肾移植术后12、24个月血肌酐升高的独立危险因素。

Objective To study the relatives living donor renal transplantation postoperative serum creatinine increases the risk factors of different stages. Methods Collected in August 2012 to August 2014 during organ transplantation（line relatives living in zhengzhou people’s hospital clinical data of 138 cases of renal transplantation patients,the serum creatinine values to our college 〉 133 μmol/L of elevated serum creatinine,eliminateacute,rejection,acute,CNIdrugs,poisoning/regurgitation,pulmonary infection,ureteral obstruction,renal allograft renal vascular stenosis and drug concentration can lead to kidney damage factors such as high or low,included in the total of 120 patients with renal transplantation. Using SPSS 13.0 statistical software Logistic regression model for the six months after renal transplantation patients,12 months and 24 months of elevated serum creatinine factors is analyzed. Results Factor analysis more prompt： donor age influence the 6 months after renal transplantation in patients with elevated serum creatinine independent risk factors,the odds ratio（OR） = 1.118. Donor age and recipient serum triglyceride（TG）,body mass index（BMI）receptor is 12 months after renal transplantation in patients with elevated serum creatinine and independent risk factors,respectively OR = 0.931,0.264,0.720. Systolic blood pressure donor age,receptors,receptor BMI is 24 months after renal transplantation in patients with elevated serum creatinine and independent risk factors,respectively OR = 0.935,1.061,0.787. Conclusion Donor age patients after renal transplantation is 6 months,12 months and 24 months of elevated serum creatinine independent risk factors; In addition,obesity is also affect the 12 months after renal transplantation in patients with elevated serum creatinine and 24 months of independent risk factors.