黄芪注射液治疗有机磷杀虫剂中毒致迟发性神经病

The Effect of Huangqi Injection in the Treatment of Tardive Neuropathy Caused by Acute Organophosphorous Insecticide Poisoning

目的 :观察黄芪注射液对急性有机磷杀虫剂中毒所致的迟发性神经病的治疗作用。方法 :采用Doll法将有机磷杀虫剂中毒患者 3 4例随机分为两组。对照组 18例 ,采用常规方法治疗 (维生素B12 5 0 0 μg ,im ,每周 2次 ;维生素B6、维生素B1、三磷腺苷各 2 0mg ,复方丹参片 3片 ,均口服 ,tid ;并给予对症、支持治疗等 )。治疗组 16例 ,则在常规方法基础上加用黄芪注射液 3 0mL加入 0 .9%氯化钠注射液 2 0 0mL中静脉滴注 ,bid ,用 6d ,停 1d ,3个月为 1个疗程。观察其迟发性神经病患者肌力恢复的情况 ,并采用肌电图测试正中神经和腓总神经的传导速度。结果 :治疗组显效率43 .7% ,对照组显效率 5 .6% (P <0 .0 1) ;治疗组肌力及神经传导速度恢复情况明显优于对照组 ,差异有极显著性 (P <0 .0 1)。结论 :黄芪注射液对急性有机磷杀虫剂中毒所致的迟发性神经病有较好的治疗作用。

Objective:To survey the curative effects of Huangqi injection in the treatment of tardive neuropathy caused by acute organophosphorous insecticide poisoning. Methods:34 cases were randomly divided into two groups according to methods described by Doll. Patients of the control group (18 cases) were subjected to conventional therapy[vitamin B 12 500 μg,I.M.,twice a week;20 mg each of vitamin B 6, vitamin B 1 and ATP 3 tablets of Fufangdanshen (red sage root) tablet, p.o., t.i.d.; symptomatic and supporting treatment]. On the basis of the conventional therapy, patients of the treatment group (16 cases) were given each additionally 30 ml of Huangqi injection in 200 mL of 0.9% sodium chloride injection administered by intravenous dripping, b.i.d., for 6 consecutive days per week. The course of treatment lasted 3 months. The state of the recovery of myodynamia in patients with tardive neuropathy was kept under observation, and the conduction velocity of the common fibular nerve and the median nerve was tested with electromyograph. Results:The rate of prominent therapeutic effectiveness in the treatment group was 43.7%, while that of the control group, 5.6%( P <0.01). The recovery of myodynamia and the conduction velocity of the nerves in patients of the treatment group was remarkably better than that of the control group, the difference being highly significant ( P <0.01). Conclusion: Huangqi injection was found to have a fairly good curative effect in the treatment of tardive neuropathy caused by acute organophosphorous insecticide poisoning.