射频超声技术定量评价慢性乙肝患者颈总动脉弹性的临床研究

Evaluation of common carotid artery elasticity in chronic hepatitis B patients using radio frequency ultrasonography

目的应用射频超声血管定量技术检测慢性乙肝(CHB)患者的颈总动脉弹性,评价CHB对颈总动脉弹性的影响。方法选取40例CHB患者(CHB组)和34例年龄、性别与之匹配且无肝病病史的健康成人(对照组),分别应用射频超声技术和肝脏声辐射力脉冲成像(ARFI)获取颈总动脉弹性参数,包括血管内-中膜厚度(IMT)、脉搏波传导速度(PWV)、动脉管壁扩张性系数(DC)和顺应性系数(CC)、硬度指数(α)、硬度指数(β)、转折点压力[P(T1)],以及肝脏硬度参数即ARFI值,并对两组各项参数进行比较分析。结果 CHB组ARFI值明显高于对照组[(2.07±0.67)m/s vs.(1.03±0.10)m/s],差异有统计学意义(P<0.01);CHB组颈总动脉的IMT高于对照组[(581.8±115.1)μm vs.(523.4±72.2)μm],差异有统计学意义(P<0.05)。两组其余指标比较差异均无统计学意义。结论CHB患者的肝脏硬度增高将会伴随颈总动脉内中膜厚度同时增加。应用射频超声检测技术监测CHB患者颈总动脉的弹性,将有益于对其血管功能和结构的关注。

Objective To detect common carotid artery elasticity in chronic hepatitis B（CHB） patients using radiofrequency ultrasonography, and evaluate the effect of CHB on common carotid artery elasticity. Methods Forty CHB patients（CHB group） and 34 age- and sex-matched healthy volunteers（control group） underwent ARFI imaging and radio frequencyultrasonography. Data and parameters recorded were as follows： ARFI value,intima-media thickness（IMT）,pulse wave velocity（PWV）,distention coefficient（DC）,compliance coefficient（CC）,stiffness parameter（α）,stiffness parameter（β）and turning pointT1[P（T1）]. Results were compared between two groups. Results Compared with the control group,CHB group had higherin ARFI values[（2.07±0.67）m/s vs.（1.03±0.10）m/s]and IMT[（581.8±115.1）μm vs.（523.4±72.2）μm],there were significantdifference（P〈0.05）. No significant differences were found for the other parameters between two groups. Conclusion CHBpatients have higher ARFI values and increased IMT with no significant changes in functional arterial parameters,indicating thatmonitoring IMT using radio frequency ultrasonography may be valuable for CHB patients.