奥美拉唑治疗反流性食管炎临床观察

A Clinical Observation on the Treatment of Reflux Esophagitis with Omeprazole

目的 :观察奥美拉唑对反流性食管炎的疗效。方法 :15 0例经内镜证实的反流性食管炎患者用奥美拉唑2 0mg ,po ,qd ,分别于治疗 2 ,4,6周时观察反酸、烧心、反食等症状疗效 ,并于治疗 6周后胃镜复查对炎症的疗效。结果 :奥美拉唑治疗 2周 ,即可见症状明显改善 ,症状记分较治疗前明显下降 (P <0 .0 1) ,治疗 2 ,4,6周 ,症状治疗显效率分别为 5 3 .3 % ,80 .7%及 88.0 % (治疗 4周及 6周与治疗 2周相比 ,P <0 .0 1)。治疗 6周症状改善总有效率为 96.2 %。 6周后Ⅰ级食管炎治愈率为 97.5 % ,高于Ⅱ级 (75 .0 % ) ,Ⅲ级与Ⅳ级治愈率为 66.7% (P <0 .0 5 )。结论

Objective:To survey the effect of omeprazole in the treatment of reflux esophagitis. Methods:150 patients with reflux esophagitis diagnosed by endoscopy were given each 20 mg of omeprazole p.o., q.d..2, 4 and 6 weeks after the beginning of the medication, the effects of the drug on the symptoms such as sour regurgitation, heart burn and reflux of food were kept under observation. Gastroscopy was repeated 6 weeks after the beginning of the treatment for appraising the cure rate. Results:2 weeks of omeprazole treatment resulted in a dramatic abatement of symptoms, with a significant decrease in the symptoms scores( P <0.01). The rates of significant effectualness of symptomatic treatment were 53.3%, 80.7% and 88.0% after 2,4 and 6 weeks of medication, respectively. (Rates of the 4 th and 6 th weeks versus rate of the 2 nd week, P <0.01). The total effective rate of symptom abatement was 96.2% after 6 weeks of treatment. At the same time, the cure rate of Grade I esophagitis (97.5%) was higher than that (75.0%) of Grade Ⅱ esophagitis. The cure rate of Grade Ⅲ and Grade Ⅳ esophagitis was 66.7%. The differences, however, were insignificant. Conclusion:Omeprazole was found to be an effective medicine in the treatment of reflux esophagitis.