阿司匹林肠溶片联合阿托伐他汀钙片对糖尿病动脉粥样硬化的干预治疗研究

Study on the intervention therapy of aspirin enteric-coated tablets combined with atorvastatin calcium on diabetes mellitus atherosclerosis

目的:探讨阿司匹林肠溶片(aspirin enteric-coated tablets,AECT)联合阿托伐他汀钙片(atovastatin calcium,AC)对糖尿病动脉粥样硬化(atherosclerosis,AS)的疗效。方法:回顾性分析98例糖尿病合并AS患者,按治疗方法不同分为对照组和观察组,每组各49例。对照组采用AECT干预治疗;观察组在对照组基础上联合AC干预治疗。比较两组患者治疗前后糖代谢指标、脂代谢指标、颈动脉内膜厚度(intima-media thickness,IMT)及斑块厚度的变化。结果:观察组治疗后,FBG、FINS、Hb A1c、HOMA-IRI、TC、LDL、TG等糖脂代谢指标均明显低于对照组,组间比较均有统计学差异(P<0.05);两组IMT及斑块厚度均明显下降,且观察组下降幅度高于对照组(P<0.05)。结论:AECT联合AC治疗糖尿病合并AS患者,在调节血脂水平、降糖及改善胰岛素抵抗的同时,还能稳定AS,临床疗效可靠。

Objective：To discuss the clinical effects of aspirin enteric-coated tablets （AECT） combined with atorvastatin calci- um （AC） on diabetes mellitus atherosclerosis （AS）. Methods：98 cases of diabetic mellitus patients with AS were selected,they were randomly divided into control group and observation group, each group has 49 cases. The patients in the control group were treated with AECT intervention therapy,and the patients in the observation group were treated with AC based on the therapy of the control group. The changes of glucose metabolism,lipid metabolism,intima-media thickness（IMT） and plaque thicknes in the two groups before and after treatment were compared. Results ： After treatment, the glucose metabolism （ such as FBG, FINS, HbA1 c, HOMA-IRI, TC, LDL, TG） in the observation group was significantly lower than that in the control group,There were statistically significant differences be- tween groups （ P 〈 0.05 ）. The IMT and plaque thicknes in the two groups significantly decreased, and descent range in the observation was higher than that in the control group （P 〈 0.05 ）. Conclusion：The therapy of AECT combined with AC for diabetic mellitus patients with AS can regulate the blood lipid level, reduce blood glucose and improve insulin resistance（1R） , stabilize AS, and has a good clini- cal curative effect.