血清CRP、SAA对慢性阻塞性肺疾病患者综合评估的意义及与肺功能的相关性研究

Research on Clinical Significance of Serum CRP and SAA in Patients with Chronic Obstructive Pulmonary Disease after Comprehensive Assessment and Correlation with Lung Function

目的探讨慢性阻塞性肺疾病(COPD)患者综合评估分组中急性加重时血清C反应蛋白(CRP)、血清淀粉样蛋白A(SAA)的浓度变化以及与肺功能的相关性研究。方法取慢性阻塞性肺疾病患者139例,根据GOLD2015年指南,对COPD患者稳定期情况进行综合评估后分为A组(23例)、B组(19例)、C组(51例)、D组(46例);分别测定其急性加重时血清CPR、SAA的浓度,并与肺功能损伤严重程度进行相关性分析。结果 D组的血清CRP、SAA浓度最高,与A、C组比较,差异有统计学意义(P<0.05),B组浓度普遍高于C组;COPD患者肺功能损伤程度与血清CRP、SAA浓度呈负相关(P<0.05)。结论血清CRP、SAA浓度的改变,有助于综合评估COPD患者,为COPD患者的治疗及管理提供客观依据;同时,检测CRP、SAA浓度有利于评估肺功能的损伤程度。

Objective To explore the changes of serum CRP and SAA in patients with comprehensive assessment COPD group, and correlation with lung function. Methods We selected 139 cases patients with COPD. According to the guide of GOLD 2015, the COPD patients were divided into group A（23 cases） , group B（ 19 cases） ,group C（51 cases） and group D（46 cases）. Analysis of the correlation between serum CRP and SAA level and injury severity of pulmonary function was perforined. Results Compared with group A, C, the group D had significance and had the highest level of serum CRP, SAA （P 〈 0.05）. Group B was higher than group C. The Lung function damage degree was negatively correlated with the level of CRP and SAA in patients with COPD （P 〈 0.05）. Conclusion The change of the concentration of serum CRP,SAA will contribute to the evaluation of patients with COPD and provide objective basis for the treatment and management of patients with COPD. Detection of CRP, SAA is helpful to evaluate the damage degree of lung function.