孕中期血清中C反应蛋白与胎膜早破、早产的相关性研究

Correlation of Pregnant Metaphase Serum CRP and Premature Rupture of Membranes and Preterm Birth

目的研究孕中期血清中C反应蛋白(CRP)与胎膜早破、早产的相关性。方法取300例孕妇孕中期空腹肘正中静脉血3ml采用免疫比浊法测定血清CRP水平,均随访至分娩结束,其中足月胎膜早破16例、早产28例,足月产256例,比较3组孕中期血清CRP水平,分析孕中期血清CRP水平的最佳界值对胎膜早破与早产的预测价值。结果足月胎膜早破组与早产组孕中期血清CRP水平均显著高于足月产组(P<0.05),但足月胎膜早破组与早产组间比较差异无统计学意义(P>0.05),最佳界值分别为13.9、10.8mg/L;孕中期时血清CRP≥13.9mg/L对足月胎膜早破的预测敏感度为68.75%,特异性为98.94%;孕中期时CRP≥10.8mg/L对早产的预测敏感度为75.00%,特异性为98.90%。结论孕中期血清CRP水平超过一定范围会明显增加足月胎膜早破与早产的可能性,对足月胎膜早破与早产有一定的预测价值。

Objective To explore the correlation of pregnant metaphase serum CRP and premature rupture of membranes and pre- term birth. Methods Totally 300 cases maternals in pregnant metaphase were sampled to collected their fasting venous blood in the mid- dle of elbow to detected the levels of serum CRP by immunoturbidimetry,and allof the materna＇s were received follow - up until end of the delivery. Of the 300 cases,there were 16 cases with premature rupture of membranes,28 cases with preterm birth,and 256 cases with full - term birth. The levels of serum CRP in pregnant metaphase of the three groups were compared,and the value of threshold to predict pre- mature rupture of membranes and preterm birth was analyzed. Results The levels of serum CRP in pregnant metaphase of the groups of premature rupture of membranes and preterm birth were hoth higher than the group of full- term birth（ P 〈 0.05 ） ,but there were not sig- nificant difference between the two groups（ P 〉 0.05 ） , and the threshold of the serum CRP were 13.9,10.8mg/L respectively. The sensi- tivity of serum CRP in pregnant metaphase to predict premature rupture of membranes was 68.75% ,and the specificity was 98.94%. The sensitivity of serum CRP in pregnant metaphaseto predict preterm birth was 75.00% ,and the specificity was 98.90%. Conclusion The level of pregnant metaphase serum CRP beyond a certain range may increase the possibility of premature rupture of membranes and preterm birth ,which is valuable to predict premature rupture of membranes and preterm birth.