牛疱疹病毒Ⅰ型潜伏感染机制研究进展

Progress for latent infection mechanism induced by bovine herpesvirus-1

牛疱疹病毒Ⅰ型(BHV-1)是危害全球养牛业发展的一种重要病原,可以引起牛传染性鼻气管炎、母牛传染性脓疱性阴道炎、公牛传染性龟头包皮炎等。病毒感染后可通过逃避宿主免疫应答以及调控自身基因表达,在宿主的三叉神经节建立终身潜伏感染,当再次受到应激因素刺激后被重新激活产生感染性,因此给BHV-1的控制和消灭造成了极大的困难。本文将对BHV-1的潜伏感染机制作以概述,从而为BHV-1的防控以及特效药物的开发提供理论参考。

Bovine herpesvirus-l（BHV-1）, a leading viral etiology for cattle worldwide, is re- sponsible for infectious bovine rhinotraeheitis, infectious pustular vulvovaginitis and infec- tious pustular balanoposthitis. A defining feature of BHV-1 is the capacity to establish the la- tent infection in the trigeminal of ganglion to escape the immune response and regulating their own gene expression, and latent viruses will be reactivated to produce infectious viruses when cattle are under stress. So it is difficult to control and eliminate the diseases associated with BHV-1. This article reviewed current progress about the mechanism of latent infection induced by BHV-1 to facilitate development of specific drugs and administration of control methods.