塞克硝唑凝胶剂的研制与含量测定

Preparation and Content Determination of Secnidazole Gel

目的 :制备塞克硝唑凝胶剂并建立含量测定方法。方法 :应用聚羧乙烯 941作辅料制备塞克硝唑凝胶剂 ,用一阶导数分光光度法测定凝胶剂中塞克硝唑的含量 ;结果 :塞克硝唑凝胶剂平均回收率 99.9% ,RSD 0 .2 0 6%。结论 :聚羧乙烯可作为辅料制备塞克硝唑凝胶剂 ,一阶导数分光光度法测定准确可靠。

Objective:To prepare a secnidazole gel and set up a method of its content determination. Method:Carboxyvinyl polymer 941 as the excipient in the preparation of the gel, and first order derivative spectrophotometry was used in the content determination of the gel. Results:The gel prepared was even and stable, with an average rate of recovery of 99.9% ( RSD 0.206%). Conclusion:Carboxyinyl polymer may serve as the excipient in the preparation of secnidazol gel. Determination of the content with first order derivative spectrophotometry was accurate and reliable.