可乐保林片中盐酸可乐定含量测定

Determination of Clonidine Hydrochloride in Clobolin Tablets

目的 :建立可乐保林片盐酸可乐定含量测定方法。方法 :运用离子对萃取 -分光光度法 ,检测波长为 412nm。结果 :盐酸可乐定在 10 .3～ 61.8μg·mL 1范围内与吸光度呈线性关系 ,平均回收率 98.6% ,RSD =1.78%。结论 :该方法准确 ,可用于测定可乐保林片中盐酸可乐定的含量。

Objective:To set up a method for the determination of clonidine hydrochloride in clobolin tablets. Method:Ion pair extraction and spectrophotometry were used and the detection wavelenth was 412 nm. Results:A linear relationship was found when the content of clonidine hydrochloride was in a range of 10.3～61.8 mg·mL 1 The average recovery was 98.6%, with an RSD of 1.78%. Conclusion:The method is accurate and suitable for the determination of clonidine hydrochloride in clobolin tablets.