硫酸钙、β-TCP及生物活性玻璃治疗颌骨囊肿的疗效观察

Comparison of Medical Calcium, β-tricalcium Phosphate, and Perioglas in the treatment of Odontogenic Cystic Cavities

目的 :观察硫酸钙、β-TCP(β-磷酸三钙)及生物玻璃(倍骼生)在颌骨囊肿治疗中的疗效。方法 :颌骨囊肿病例45例,行囊肿刮除术后,随机分为4组,骨腔内填充不同物质。A组:硫酸钙组;B组:β-TCP组;C组:生物玻璃(倍骼生)组;D组:空白组。术后观察患者术区肿胀程度,且1、3、6、12个月后拍摄CBCT或全景片,观察术区骨愈合情况。结果:A组患者术后1周内术区肿胀明显;A、C组患者6个月后,术区与正常骨组织无明显区别;B组患者12个月后,新骨几乎充填整个骨腔;D组新骨形成明显较A、B、C组慢。结论:在新骨形成方面,A、B、C组分别与D组相比,差异均有统计学意义;硫酸钙会引起部分患者术区肿胀反应。

Objective： To observe the different effect of medical calcium,β-tricalcium phosphate （β-TCP）and Perioglas in the treatment of odontogenic cysts cavities. Methods： Screen 45 cases of jaw cyst randomly. After cyst curettage operation, according to the different bone cavity filling materials, these cases divided into four groups, Group A： Medical calcium; Group B： Calcium phosphate; Group C： Perioglas; Group D： Blank group. Observations included the swelling degree of surgical site; Regular x-ray examination was performed at 1, 3, 6, 12 months intervals to realise the bone regeneration. Results： In group A, the swelling of surgical site was obvious after operation. In group A and group C, after 6 months of operation, there was no significant difference between the operative region and surrounding normal bone tissue. Group B： 12 months later, the material was completely absorbed, and the new bone was almost filled with the whole bone cavity. Group D： The rate of the new bone formation was significantly retarded than that of A, B, and C groups. Conclusion： Comparison between group A, B, C and group D, the rate of new bone formation differed significantly. Medical calcium sulfate could cause swelling reaction in the operation area.