摘要
口腔头面部疾病及外伤均可导致口腔颌面部及牙齿周围骨组织缺损。组织工程骨是修复口腔颌面部骨和牙周组织缺损的重要手段,而理想的种子细胞是得到组织工程骨的必要条件。牙髓干细胞容易获取,病原携带率低,培养效率高,具有成骨分化能力,与多种生物活性材料亲和性高,是组织工程修复骨缺损的理想种子细胞。本文对牙髓干细胞在口腔颌面部及牙周组织工程骨中的应用研究进展进行综述。
Maxillofacial and periodontal bone defect can be caused by multiple diseases. Bone tissue engineering is an effective method to repair bone defects in maxillofacial and periodontal area. To achieve this, ideal seed cells are essential. Dental pulp stem cells （DPSCs） have been demonstrated to possess several appealing qualities： convenient access to the collection site, low morbidity, high efficiency during extraction and culture, osteogenic differentiation potential, and high interactivity with scaffold materials. Hence DPSCs become an ideal seed cell for tissue-engineered bone. In this review, we will look into the applications of DPSCs in maxillofacial and periodontal tissue-engineered bone.
作者
齐颖(综述)
赵玉梅(审校)
QI Ying ZHAO Yu-mei(Department of Pediatric Dentistry, School and Hospital of Stomatology, Tongji University,Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, Chin)
出处
《口腔颌面外科杂志》
CAS
2016年第6期446-451,共6页
Journal of Oral and Maxillofacial Surgery
基金
上海市科学技术委员会科研计划项目(14411963600)
关键词
牙髓干细胞
成骨分化
颌面部骨缺损
牙周骨缺损
组织工程骨
dental pulp stem cells （DPSCs）
osteogenic differentiation
maxillofacial bone defects
periodontal bone defects
tissue-engineered bone
