丙种球蛋白治疗川崎病两种方案的疗效比较

Comparison of Two Dosage Schemes of Intravenously Administered Gamma Globulin for the Treatment of Patients with Kawasaki Disease

目的 :评价单剂丙种球蛋白对川崎病的疗效。方法 :将 2 6例患者随机分为单剂组 (15例 )和多剂组 (11例 )。单剂组给予丙种球蛋白 2g·kg 1,一次静脉滴注 ;多剂组给予丙种球蛋白 40 0mg·kg 1·d 1,静脉滴注 ,连用 5d。两组都加用阿司匹林口服。结果 :总发热时间单剂组 (9.7± 3 .1)d ,较多剂组 (11.4± 5 .3 )d短 ,差异有显著性 (P <0 .0 5 )。单剂组EKG异常占 10 .7% ,较多剂组 2 4.8%低 ,差异有显著性 (P <0 .0 5 )。单剂组冠状动脉损害占 18.1% ,较多剂组2 5 .3 %减少 ,差异有显著性 (P <0 .0 5 )。结论

Objective:To evaluate the therapeutic effectiveness of single high dose of gamma globulin in the treatment of patients with Kawasaki disease (KD). Methods:26 patients with KD were randomly divided into two groups. Patients of the treatment group( n =15)were given each a single dose of gamma globulin (2 g·kg 1 ) by intravenous dripping while each patient of the control group( n =11) received a daily intravenous dripping of 400 mg·kg 1 of gamma globulin for five consecutive days. Patients of both groups were given aspirin p.o. additionally. Results:The total febrile period of patients of the treatment group (9.7±3.1 days) was shorter than that (11.4±5.3 days) of the control group( P <0.05). The incidence of EKG abnormalities in patients of the treatment group (10.7%) was lower than that (24.8%) of the control group ( P <0.05). The incidence of impairments of coronary arteries in patients of the treatment group (18.1%) was also lower than that (25.3%) of the control group( P <0.05). Conclusion:Single high dose of gamma globulin administered intravenously was found to be effective in the prevention and treatment of cardiovascular impairment in patients with KD.