胃ESD术后溃疡愈合的影响因素分析

The risk factors of gastric ulcer healing after endoscopic submucosal dissection(ESD)

目的:分析胃黏膜病变行内镜下黏膜剥离术(ESD)后溃疡愈合的相关危险因素。方法:选取由于胃黏膜病变行胃ESD术55例患者,观察手术时间、术中是否出血、手术部位,手术创面大小及术后6周胃镜复查时溃疡的大小、分期及溃疡愈合率,进行单因素和多因素Logistics回归分析。采用SPSS 17.0统计学软件包进行统计分析。结果:对ESD术后6周溃疡愈合的单因素分析表明,手术创面大小、术中创面是否出血、病变病理分型与溃疡愈合显著相关(P<0.05);多因素Logistics回归分析表明仅手术创面大小与溃疡愈合显著相关(P<0.05)。结论:手术创面大小是影响ESD术后医源性溃疡愈合的重要影响因素。

Objective：The objective of this paper is to discuss the risk factors of gastric ulcer healing after endoscopic submucosal dissection（ESD）.Methods：Fifty-five patients performed on ESD surgery, enrolled in the Department of Gastroenterology, the Second Affiliated Hospital of Shihezi University Medical College, were selected as the research object and various methods such as the single factor and multi-factor logistics regression analyses are deployed through the record of operation time, bleeding condition, operation part, surgical wound and ulcer size, staging and healing rate 6 weeks after the operation. Additionally, statistical software package SPSS 17.0 is also used for this study.Results：The logistic regression analysis 6 weeks after the operation showed that there was significant correlation between the size of the wound, the bleeding of the wound and the ulcer healing（P〈0.05）.The multivariate logistic regression analysis showed that only the surgical wound size was significantly correlated with ulcer healing（P〈0.05）.Conclusion：Surgical wound size is an important factor influencing healing of iatrogenic ulcer after ESD operation.