抑制PI3K信号通路的抗肿瘤天然药物研究进展

Research progress on antitumor natural products of inhibiting PI3K signaling pathway

磷脂酰肌醇3-激酶(PI3K)信号通路是正常细胞生理代谢的重要信号转导途径,也是肿瘤细胞发生和发展的关键信号通路。人类肿瘤基因组学研究表明,PI3K信号通路可将癌基因和多种受体与许多细胞功能联系在一起,该通路也是肿瘤中最常被激活的通路,抑制该信号通路,可抑制肿瘤的生长与转移。概述了PI3K及其信号通路与肿瘤发生、发展和转移的关系以及PI3K信号通路的主要抑制途径,综述近年来抗肿瘤天然药物抑制PI3K信号通路的研究进展。

The phosphoinositide 3-kinase （PI3K） signal pathway, an important signal transduction pathway in the normal cell physiological metabolism, is well associated with the occurrence and development of malignancies. The research about human cancer genomics shows that PI3K signaling pathway can link cancer genes and multiple receptors with many cellular functions, and PI3K signaling pathway is the most common activated pathway in cancer. Therefore, inhibition of PI3K signaling pathway will suppress tumor growth and metastasis. In this paper, the relationship between PI3K signaling pathway and the occurrence, development and metastasis of malignancies, and the major inhibitory way against PI3K signaling pathway were outlined. Especially, the research progress on the molecular mechanisms of inhibiting PI3K signaling pathway by anti-tumor natural products was reviewed.