妊娠期肝内胆汁淤积症患者血清胆汁酸水平对围生儿结局的影响

Effect of serum bile acid level in patients with intrahepatic cholestasis of pregnancy on perinatal outcomes

目的探讨妊娠期肝内胆汁淤积症患者血清胆汁酸水平对围生儿结局的影响。方法选取2014年6月-2016年6月收治的90例妊娠期肝内胆汁淤积症患者作为观察组,另选择同期收治的90例健康孕妇作为对照组。比较两组孕妇血清及胎儿脐血胆汁酸水平及围生儿结局。结果观察组孕妇血清及胎儿脐血胆汁酸水平均高于对照组,差异均有统计学意义(P<0.05)。Spearman相关性分析显示:观察组胎儿脐血胆汁酸水平与孕妇血清胆汁酸水平呈正相关(r=0.982,P<0.05)。与对照组相比,观察组新生儿Apgar评分较低,新生儿窒息率、围生儿死亡率及早产率均较高,差异均有统计学意义(P<0.05)。结论检测孕妇血清及胎儿脐血胆汁酸水平具有重要意义,可为评估围生儿结局提供一定的理论基础。

Objective To explore the effect of serum bile acid level in patients with intrahepatic cholestasis of pregnancy（ ICP） on perinatal outcomes. Methods Ninety ICP patients treated in the hospital from June 2014 to June 2016 were selected as observation group,and ninety healthy pregnant women treated in the hospital during the same period were selected as control group. The levels of maternal serum and fetal umbilical cord blood bile acid and perinatal outcomes in the two groups were compared. Results The levels of maternal serum and fetal umbilical cord blood bile acid in observation group were statistically significantly higher than those in control group（ P 0. 05）. Speaman correlation analysis showed that fetal umbilical cord blood bile acid level was positively correlated with maternal serum bile acid level in observation group（ r = 0. 982,P 0. 05）. Compared with control group,neonatal Apgar score in observation group was lower,the incidence rate of neonatal asphyxia,perinatal mortality,and premature birth rate were higher,there were statistically significant differences（ P〈0. 05）. Conclusion Detecting maternal serum and fetal umbilical cord blood bile acid levels is of important significance,which can provide a certain theoretical basis for evaluating perinatal outcomes.