宫腔内持续放置水囊联合大剂量雌激素对宫腔粘连分离术后再粘连、月经恢复及妊娠率的影响

Effect of continuous administration of intrauterine water sac combined with large-dose estrogen on readhension,menstrual recovery,and pregnancy rate after transcervical resection of adhesion

目的探讨宫腔内持续放置水囊联合大剂量雌激素对宫腔粘连分离术后再粘连、月经恢复及妊娠率的影响。方法选取2013年1-12月收治的宫腔粘连分离术患者86例,随机平均分为研究组和对照组。对照组给予宫腔内水囊联合低剂量雌激素治疗,研究组应用宫腔内水囊联合大剂量雌激素治疗,对比两组患者的疗效、凝血功能及子宫内膜厚度。结果研究组患者的术后再粘连率显著低于对照组,月经恢复正常率及妊娠率显著高于对照组,差异均有统计学意义(均P<0.05)。两组患者手术前凝血酶时间和纤维蛋白原比较差异无统计学意义(P>0.05);手术后凝血酶时间和纤维蛋白原比较差异均有统计学意义(均P<0.05)。两组患者手术前子宫内膜厚度比较差异无统计学意义(P>0.05);手术后子宫内膜厚度比较差异均有统计学意义(均P<0.05)。结论宫腔粘连分离术患者应用宫腔内水囊联合大剂量雌激素有利于预防术后再粘连,恢复正常月经,提高患者妊娠率。

Objective To explore the effect of continuous administration of intrauterine water sac combined with large-dose estrogen on readhension,menstrual recovery,and pregnancy rate after transcervical resection of adhesion Methods Eighty-six patients underwent transcervical resection of adhesion in the hospital from January to December in 2013,then they were randomly divided into study group and control group. The patients in control group were treated by intrauterine water sac combined with low-dose estrogen,and the patients in study group were treated by intrauterine water sac combined with large-dose estrogen. The curative effects,coagulation function,and endometrial thicknesses in the two groups were compared. Results The incidence rate of postoperative adhesion in study group was lower than that in control group,menstrual recovery rate and pregnancy rate in study group were higher than those in control group,there were statistically significant differences（ all P〈0. 05）. There was no statistically significant difference in preoperative thromboplastin time and fibrinogen level between the two groups（ P〉0. 05）; there were statistically significant differences in postoperative thromboplastin time and fibrinogen level between the two groups（ all P〈0. 05）. There was no statistically significant difference in preoperative endometrial thickness between the two groups（ P〉0. 05）; there was statistically significant difference in postoperative endometrial thickness between the two groups（ P〈0. 05）.Conclusion Intrauterine water sac combined with large-dose estrogen in the treatment of patients after transcervical resection of adhesion can prevent postoperative adhesion,restore normal menstruation,and improve pregnancy rate.