利拉鲁肽对2型糖尿病大鼠肾脏保护作用的研究

The Protective Effect of Liraglutide on Kidney in Type 2 Diabetic Rats

目的观察利拉鲁肽对2型糖尿病大鼠肾脏的保护作用。方法雄性SD大鼠给予高糖高脂饲料喂养6周后空腹注射链脲佐菌素(STZ)建立2型糖尿病大鼠模型,成模的大鼠每天给予利拉鲁肽(200μg/kg体质量)皮下注射6周,与对照组相比,观察其血糖、血压、体质量、血尿素氮、血肌酐和血尿离子的变化。结果利拉鲁肽能有效降低模型大鼠的血糖、血压、体质量、血尿素氮和肌酐,调节尿离子浓度。结论利拉鲁肽通过调节2型糖尿病大鼠血压和尿离子浓度,发挥其肾脏保护作用。

Objective To observe the protective effect of Liraglutide on kidney in type 2 diabetic rats. Methods The male SD rats were injected with streptozotocin （STZ） in fasting condition by intraperitoneal injection after 6-week high-fat and high-sugar feeding to establish the type 2 diabetic rat models. The type 2 diabetic rats were given Liraglutide 200btg/kg each day by subcutaneous injection for 6 weeks, and the changes of blood glucose, blood pressure, body weight, urea nitrogen, serum creatinine and ion concentration in urine were detected. Results Liraglutide decreased the blood glucose, blood pressure, body weight, urea nitrogen and serum creatinine and regulated the ion concentration in urine in the type 2 diabetic rat models in an effective way. Conclusion Liraglutide can exert a protective effect on the kidney by regulating the blood pressure and urinary ionic concentration in type 2 diabetic rats.